Research News from across Africa and beyond

Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction

Authors: Zhaoyue Men, Zishen Lin, Z P Wang, Peng Tan, Shuyang Yu et al.

Journal of Biomedical Science

Itaconate has garnered significant attention in recent years due to its immunomodulatory and antimicrobial functions. During inflammation and pathogenic infections, itaconate is formed through the de…

Plant-based edible vaccines: from transgenic food crops to post-pandemic molecular farming and genomics-informed vaccine platforms

Authors: Ibrokhim Abdurakhmonov

Discover Plants.

Plant-based edible vaccines began as an unusually attractive promise: a recombinant antigen produced in a familiar crop and delivered through the logic of food rather than injection. Rooted in earlie…

Editorial: HIV-1 Tat, an enhancer of virus infectivity and disease promoter: target for preventive and therapeutic interventions

Authors: Aurelio Cafaro, Jonathan Karn, Ben Berkhout, Susana Valente, Barbara Ensoli

Frontiers in Immunology

Although antiretroviral therapy (ART) effectively suppresses plasma viremia, individuals with HIV still experience ongoing immune activation, tissue dysfunction, and non-AIDS-related health issues. T…

Reaktif, Enfeksiyöz, İnflamatuar ve Tümör Benzeri Lenfadenopatiler

Authors: Züleyha Çetindağ, Sena Öztürk Efe, Sedanur Aydın, Muhammed Emin Öz, Seda Keskin Gökmen et al.

Unknown Journal

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Malignancy as a rising contributor to mortality in patients with inflammatory bowel disease: a population-based epidemiological study

Authors: Amr Ibrahim, Mahmoud Shaaban Abdelgalil, Sara Hosny El-Farargy, Rahma Sameh Shaheen, Moaz Yasser Darwish et al.

International Journal of Colorectal Disease

BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with increased malignancy risk. This study assessed national trends in malignan…

Microbiome and cancer immunotherapy: a bibliometric analysis

Authors: Wenbin Tan

Journal of the Egyptian National Cancer Institute

OBJECTIVE: To systematically analyze the global research landscape, collaboration patterns, knowledge flow pathways, and frontier trends in the synergistic effects between the microbiome and cancer i…

Development of an Env based HIV mRNA vaccine through immunoinformatics and computational modeling

Authors: Akmal Zubair, Maded Aldohri, Faisal Ahmad, Muhammad Yaqoob Shahani, Naila Afghan

Scientific Reports

The Human Immunodeficiency Virus (HIV) is a significant challenge to the global healthcare system. Recent efforts to develop an effective immune-stimulatory vaccine for HIV-1 have attracted considera…

Impact of Gene Polymorphism rs2275913 and Serum IL-17A Levels on Liver Fibrosis Severity Across the Natural History of Chronic Hepatitis B in Indonesia

Authors: Ummi Maimunah, Andrio Palayukan, Juniastuti Juniastuti, Brahmana Askandar Tjokroprawiro, Muhammad Miftahussurur

Diseases

Background: A complex interplay between viral activity and host immune responses drives the progression of liver fibrosis in chronic hepatitis B. The T helper 17 (Th17) immune pathway, which produces…

Psychosocial Challenges of COVID 19 on Adolescent Students in Awi zone, Ethiopia

Authors: Mintesnot Fentahun

Research Square

Coevolving Mutations in Chronic SARS-CoV-2 Infections

Authors: Ryan Hisner, Ravindra K. Gupta, Darren P. Martin

bioRxiv (Cold Spring Harbor Laboratory)

The SARS-CoV-2 pandemic has been marked by two outstanding features that have had major impacts on global public health: the repeated emergence and growth of highly divergent saltation variants with …